Skip to main content
Figure 7 | Molecular Pain

Figure 7

From: Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

Figure 7

Blockade of the JWH015 effects in microglial migration by MKP-1 and MKP-3 inhibition. (A) JWH015 1 μM (JWH 1) significantly reduced the number of LPS-stimulated microglia that migrated towards ADP and triptolide 10 μM (Trip 10) blocked this effect. Triptolide 10 μM did not modify the number of LPS-stimulated microglia that migrated towards ADP. *p < 0.05 vs. JWH015 group. (B) Representative photomicrographs of the migration chamber membranes with attached microglial cells stained with crystal violet. Cells (black) migrated through the pores (white circles) and towards ADP placed into the lower well.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us