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Figure 1 | Molecular Pain

Figure 1

From: Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

Figure 1

Effects of spinally administered rapamycin onbaseline neuronal responses. A. C-fibre mediated transmission onto WDR neurones was significantly inhibited by rapamycin (n = 9) compared to DMSO (n = 10). B. In some cases, there were strong trends for inhibition (as shown in example) by rapamycin of wind up, yet overall, these changes were not significant. C. Rapamycin significantly inhibited responses to 8, 15, 26 and 60 g von Frey filaments when compared to DMSO. D. Rapamycin exerted a significant inhibitory effect on the responses evoked by 35°C. (A. 1 way ANOVA with repeated measures and Dunnett's post-tests. C and D. 2 way ANOVA with repeated measures and Bonferroni's post-tests, *P < 0.05, **P < 0.01, ***P < 0.001).

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