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Figure 2 | Molecular Pain

Figure 2

From: Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

Figure 2

Effects of spinally administered mRNA translation inhibitors on formalin-induced neuronal hyperexcitability. A. Pooled data of responses from WDR neurones during the formalin test. When rapamycin (n = 9) was administered onto the exposed spinal cord 3 min prior to 5% formalin injection into the hind paw, there was significant reduction in neuronal activity in the second phase of the test compared to when DMSO (n = 11) was administered to the exposed spinal cord. B. Similarly, when the global translation inhibitor anisomycin (n = 7) was administered onto the exposed spinal cord 3 min prior to formalin injection into the hind paw there was also a significant reduction in neuronal activity in the second phase of the test compared to when DMSO (n = 6) was administered (2 way ANOVA with repeated measures and Bonferroni's post-tests, *P < 0.05; **P < 0.01).

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Molecular Pain

ISSN: 1744-8069

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