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Figure 3 | Molecular Pain

Figure 3

From: Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

Figure 3

Effects of spinally administered rapamycin on formalin-induced behavioural hypersensitivity. A. When rapamycin (n = 6) was administered spinally 20 min prior to 5% formalin injection into the hind paw, there was significant reduction in total behavioural hypersensitivity in both the first and second phase of the formalin test compared to when rats were spinally pre-treated with DMSO (n = 6). B. Specifically, licking and biting behaviour was attenuated when rats were pre-treated with rapamycin. C. Lifting and flinching behaviour however, was unaffected (2 way ANOVA with repeated measures and Bonferroni's post-tests, *P < 0.05, **P < 0.01).

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