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Table 1 WDR neurones selected for DMSO or rapamycin treatment prior to hind paw formalin injection comprised equal populations for all measures

From: Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

 

DMSO (n = 11)

Rapamycin (n = 9)

Depth (μM)

777 ± 36

790 ± 51

Aβ-fibre threshold (μA)

0.27 ± 0.10

0.23 ± 0.11

C-fibre threshold (μA)

0.78 ± 0.17

0.55 ± 0.13

Aβ-fibre spikes

104 ± 9

104 ± 16

Aδ-fibre spikes

92 ± 18

93 ± 19

C-fibre spikes

310 ± 49

315 ± 39

Post-discharge spikes

82 ± 29

133 ± 39

Input spikes

298 ± 59

292 ± 57

Wind up spikes

130 ± 33

233 ± 68

35°C spikes

179 ± 52

102 ± 34

40°C spikes

374 ± 91

263 ± 85

45°C spikes

618 ± 67

693 ± 62

48°C spikes

579 ± 104

513 ± 118

50°C spikes

777 ± 91

888 ± 79

  1. All data are expressed as raw mean values ± SEM. There were no significant differences between cells that had the DMSO treatment prior to formalin injection or those that were treated with rapamycin prior to formalin injection (unpaired t-tests, except for graded thermally-evoked responses whereby 2 way ANOVA with Bonferroni's post-tests were used).