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Table 2 WDR neurones selected for DMSO or anisomycin treatment prior to hind paw formalin injection comprised equal populations for all measures

From: Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

 

DMSO (n = 7)

Anisomycin (n = 6)

Depth (μM)

890 ± 85

771 ± 33

Ab-fibre threshold (μA)

0.70 ± 0.04

0.53 ± 0.11

C-fibre threshold (μA)

1.73 ± 0.24

1.64 ± 0.16

Aβ-fibre spikes

224 ± 40

176 ± 29

Aδ-fibre spikes

189 ± 24

145 ± 26

C-fibre spikes

597 ± 79

432 ± 33

Post-discharge spikes

755 ± 113

549 ± 119

Input spikes

576 ± 112

640 ± 128

Wind up spikes

752 ± 86

486 ± 103

35°C spikes

160 ± 50

261 ± 98

40°C spikes

219 ± 49

351 ± 93

45°C spikes

626 ± 148

544 ± 104

48°C spikes

970 ± 145

904 ± 79

50°C spikes

1409 ± 103

1266 ± 97

  1. All data are expressed as raw mean values ± SEM. There were no significant differences between cells that had the DMSO treatment prior to formalin injection or those that were treated with anisomycin prior to formalin injection (unpaired t-tests, except for graded thermally-evoked responses whereby 2 way ANOVA with Bonferroni's post-tests were used).