Figure 3
From: Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays
Nerve injury-induced tactile allodynia is markedly blunted in p2rx4-/- mice. Paw withdrawal thresholds (left panel, ipsilateral hindpaw; right panel, contralateral hindpaw) of wild-type (n = 5) and p2rx4-/- mice (n = 6) before (0) and 1, 3, 7, 10 and 14 days after spinal nerve injury. (B) Cold allodynia evoked by applying acetone to the plantar surface of the ipsilateral hindpaw 7 days after nerve injury (wild-type, n = 5; p2rx4-/-, n = 5). *p < 0.05, ***p < 0.001 vs. wild-type mice. All data are presented as means ± SEM.