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Figure 3 | Molecular Pain

Figure 3

From: An in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor

Figure 3

Immunoblot analysis of phosphorylation of CaMKII, ERK and CREB proteins in the mouse SC following HFS in vivo. A-D: Representative immunoblots illustrating time courses of changes in CaMKII (A), pERK (A) and pCREB (C) and quantification of CaMKII (B), pERK (B) and pCREB (D) protein levels following HFS. E-H: Representative immunoblots illustrating changes of expression of the CaMKII (E), pERK (E) and pCREB (G) and quantification of CaMKII (F), pERK (F) and pCREB (H) protein levels with or without MK-801 treatment. Fold changes are standardized by protein level in the corresponding group of "sham" (surgery without HFS, mean value set as 1). *p < 0.05, **p < 0.01 indicates significant differences compared with that in the corresponding sham group; #p < 0.05, ##p < 0.01 indicates significant differences compared with that in the corresponding group of peak value 5 or 10 min after HFS (in B) and of "control" (surgery plus HFS) in F and H.

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