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Figure 6 | Molecular Pain

Figure 6

From: An in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor

Figure 6

Effects of EphB2-Fc and targeted mutation of EphB1 receptor on phosphorylation of CaMKII, ERK and CREB proteins in the mouse SC following HFS. A-D: Representative immunoblots illustrating changes in HFS-induced phosphorylation of CaMKII (A), pERK (A) and pCREB (C) and quantification of CaMKII (B), pERK (B) and pCREB (D) proteins after pretreatment of EphB2-Fc. E-H: Representative immunoblots illustrating changes in HFS-induced phosphorylation of CaMKII (E), pERK (E) and pCREB (G) and quantification of CaMKII (F), pERK (F) and pCREB (H) proteins in wild type (WT) and EphB1 receptor protein-null (EphB1-/-) mice. Fold changes are standardized by protein level in the corresponding group of "sham" (surgery without HFS, mean value set as 1). *p < 0.05, **p < 0.01 indicates significant differences compared with that in the corresponding sham group; #p < 0.05, ##p < 0.01 indicates significant differences compared with that in the corresponding group of IgG-Fc (as control) in B and D.

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