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Figure 3 | Molecular Pain

Figure 3

From: Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons

Figure 3

The ROS scavenger PBN blocks TNFR1 increases in cultured mouse DRG neurons induced by capsaicin or resiniferatoxin. Histograms showing the percentage of TNFR1 immunoreactive neurons in DRG neuronal cultures. (A) Capsaicin significantly increases TNFR1 staining in DRG neurons (*P < 0.05), and PBN blocks the TNFR1 increase induced by capsaicin (# P < 0.05 compared to capsaicin). (B) Resiniferatoxin significantly increases the TNFR1 increase in DRG neurons (**P < 0.01). PBN blocks the TNFR1 increase induced by resiniferatoxin (## P < 0.01 compared to resiniferatoxin). Results indicate that capsaicin and resiniferatoxin increase TNFR1 in DRG neurons through a ROS signaling pathway.

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