Figure 5
From: Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons
Capsaicin or resiniferatoxin induces ROS production in cultured mouse DRG neurons through TRPV1 activation. (A) Capsaicin significantly increases ROS production and capsazepine blocks capsaicin induced ROS production (30 minutes: ## P < 0.01 compared to capsaicin). (B) Resiniferatoxin significantly increases ROS production and resiniferatoxin blocks capsaicin induced ROS production (30 minutes: ### P < 0.001 compared to resiniferatoxin). (C) There is no change in ROS production in DRG neurons from TRPV1 deficient mice after capsaicin or resiniferatoxin stimulation.