Figure 1
Recording of Na v 1.8 currents in rat DRG neurons. A: representative I-V curve family of currents recorded in the presence of 500 nM TTX is shown, using a protocol (inset) where cells were depolarized to a variety of potentials (-55 to +40 mV) from a holding potential of -60 mV to elicit Nav1.8 currents. B: I-V curve of Nav1.8 currents shown in (A). C: representative traces of Nav1.8 current elicited by a single pulse of -10 mV which was used in most of the recordings. D: peak amplitudes of Nav1.8 currents elicited by -10 mV pulse at 5 min, 10 min and 15 min after whole-cell mode was performed. The currents were stable during the recording time in all the cells (n = 16).