Skip to main content
Figure 3 | Molecular Pain

Figure 3

From: PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

Figure 3

Involvement of PKC, but not PKA in Sar-SP-induced potentiation of Na v 1.8 currents. Incubation with PKC inhibitor BIM (1 μM) for 30 min before Sar-SP perfusion completely blocked the potentiation effect of Sar-SP in all 24 neurons tested (A and B, p > 0.05, Mann-Whitney rank sum test). After incubation with PKA inhibitor H89, Sar-SP (1 μM) still fully enhanced Nav1.8 currents in 9 of 24 DRG neurons (C and D, ***p < 0.001, Mann-Whitney rank sum test).

Back to article page