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Figure 4 | Molecular Pain

Figure 4

From: PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

Figure 4

PMA mimic the effect of Sar-SP. A and B:representative traces (A) and histogram (B) showing the effect of PMA on Nav1.8 currents. 300 nM PMA induced a similar potentiation to 1 μM Sar-SP. Perfusion with Sar-SP failed to further enhance the currents after PMA-induced peak potentiation (***p < 0.001, versus control, Kruskal-Wallis one-way ANOVA, n = 16 for control, 10 for PMA and 10 for Sar-SP). PMA also shifted the activation and steady-state inactivation curve of Nav1.8 in a hyperpolarized direction (C and D).

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Molecular Pain

ISSN: 1744-8069

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