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Figure 5 | Molecular Pain

Figure 5

From: PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

Figure 5

PKCε was the main PKC subtype mediating the effect of Sar-SP. A and B: representative traces (A) and histogram (B) showing the effect of PKCε inhibitor εV1-2 on Sar-SP-induced potentiation. Intracellular application of εV1-2 (200 μM) completely abolished the potentiation effect of Sar-SP. The negative control (control peptide) of εV1-2 failed to block Sar-SP-induced potentiation (***p < 0.001, versus normal control, one-way ANOVA, n = 16 for normal control, 11 for εV1-2 and 8 for negative control).

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