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Figure 1 | Molecular Pain

Figure 1

From: Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain

Figure 1

Chronic treatment with minocycline significantly attenuates spinal nerve ligation-induced reduction in mechanical paw withdrawal threshold. Minocycline (Mino, 30 mg/kg, ip) or vehicle (Veh, sterile water) was injected daily for 14 days and paw withdrawal threshold of the ipsilateral (Ipsi) and contralateral (Contra) hindpaw were measured using von Frey filaments (sham data not shown for clarity of figure). Data were analysed using 2-way ANOVA followed by Bonferroni's post-hoc tests, and are expressed as mean (± SEM, n = 6 rats/group). ** P < 0.01, *** P < 0.001 vs contralateral paw; δ P < 0.05, δδ P < 0.01, δδδ P < 0.001 vs vehicle-ipsilateral paw.

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Molecular Pain

ISSN: 1744-8069

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