Spinal dorsal root entry zone stimulation evoked an inward current in spinal astrocytes. In the presence of antagonists to GABAA and glycine receptors (bicuculline and strychnine), a slow-decaying inward current was recorded from a spinal astrocyte holding at -80 mV (n = 15, curve 1). Ba2+ (1 mM) largely blocked the slow-decaying inward current, but unmasked a fast-decaying inward current (curve 2, also visible with bigger scale in the lower box). A fast-decaying inward current was still largely preserved after the application of DNQX and D-AP5 to block AMPA and NMDA receptors, respectively (curve 3). All responses were from the same cell and represented averages of 5 trials.