Figure 2
From: Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes
Spinal dorsal root entry zone stimulation evoked an inward current in spinal astrocytes. In the presence of antagonists to GABAA and glycine receptors (bicuculline and strychnine), a slow-decaying inward current was recorded from a spinal astrocyte holding at -80 mV (n = 15, curve 1). Ba2+ (1 mM) largely blocked the slow-decaying inward current, but unmasked a fast-decaying inward current (curve 2, also visible with bigger scale in the lower box). A fast-decaying inward current was still largely preserved after the application of DNQX and D-AP5 to block AMPA and NMDA receptors, respectively (curve 3). All responses were from the same cell and represented averages of 5 trials.