Figure 1
From: Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
Antinociceptive effects of acute injection of NT agonists on formalin induced pain behaviors. (a) Time course of analgesic effects of NT (6 μg/kg) and NT69L (5 μg/kg). Saline and drugs were intrathecally administered 5 min before the subcutaneous injection of formalin. Nocifensive behaviors in male rats are expressed in 3 min intervals with a weighted pain score. (b, c) Pre-treatment with JMV-431 (5–60 μg/kg) or levocabastine (0.5–5 μg/kg) results in the inhibition of the persistent noxious chemical stimulation. Each symbol represents the mean ± SEM of determinations made in six to eight animals.