Figure 1

uEPSCs and mEPSCs in ACC synapses after peripheral inflammation and nerve ligation. A-C, Traces indicate 20 consecutive uEPSCs recorded at the stimulus intensity of 5 V in ACC neurons from control mouse (A), mouse following CFA injection (B), and mouse with nerve ligation (C), respectively. Representative histogram of peak amplitude of uEPSCs (100 trials) in ACC neurons from control mouse (A), mouse following CFA injection (B), and mouse with nerve ligation (C), respectively, with a Gaussian curve (Bottom). D, Representative mEPSCs recorded in pyramidal neurons at a holding potential of -70 mV from control mice, mice following CFA injection, and mice with nerve ligation. E, The mean rate (left) and amplitude (right) of mEPSCs in neurons from control mice (n = 12), mice following CFA injection (n = 8), and mice with nerve ligation (n = 9). **p < 0.01.