Figure 2
From: Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
Adenovirus-mediated expression of GAD65 in the trigeminal ganglion produces analgesia in the formalin test. Orofacial formalin tests were performed six days after the injection of AdGAD65 or one of the control viruses (AdGFP or AdLacZ) and compared to Naïve rats. After injection of AdGAD65, there is a significant reduction of the nociceptive response (RM ANOVA: F = 3.8; P < 0.001) in the second phase of the orofacial formalin test. AdGAD65 vs. Naïve: **P < 0.01, ***P < 0.001; AdGAD65 vs AdGFP: *P < 0.05, **P < 0.01, ***P < 0.001; AdGAD65 vs AdLacZ: ##P < 0.01, ###P < 0.001.