Figure 3

Mechanical sensation of the face is unchanged after adenovirus-mediated expression of GAD65 in the trigeminal ganglion. Six days after the injection of AdGAD65 or AdGFP, the rats were tested for their response to von Frey hair stimulation. For each hair, there was no difference in von Frey score between AdGAD65 and AdGFP when compared pre- and post-injection on the ipsilateral side (RM ANOVA: 2 g hair, F = 0.1, P = 0.791; 10 g hair, F = 0.0, P = 0.926; 50 g hair, F = 0.3, P = 0.566). Similarly, there was no difference between contralateral and ipsilateral von Frey score pre- and post-injection after either injection of AdGAD65 (RM ANOVA: 2 g hair, F = 2.1, P = 0.200; 10 g hair, F = 1.0, P = 0.356; 50 g hair, F = 1.0, P = 0.356) or AdGFP (RM ANOVA: 2 g hair, F = 2.3, P = 0.170; 10 g hair, F = 0.0, P = 1.000; 50 g hair, F = 4.2, P = 0.080).