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Figure 6 | Molecular Pain

Figure 6

From: The endogenous hydrogen sulfide producing enzyme cystathionine-β synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome

Figure 6

Alteration in action potential (AP) frequency. Representative traces of APs were induced by 300-ms depolarizing current pulses injected through the patch pipette at two times rheobase in DiI labeled neurons from control rats under current-clamp conditions. (A) AP recorded before (PRE) application of H2S donor NaHS. (B) APs recorded after 2 mins perfusion of H2S donor NaHS (250 μM). Application of NaHS significantly increased the APs frequency evoked by two times rheobase electrical stimulation. (C) APs recorded after 10 min wash. (D) Bar graph showing a significant increase in average number of APs elicited by a two times rheobase current injection after application of NaHS (*P < 0.01 compared with PRE).

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Molecular Pain

ISSN: 1744-8069

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