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Figure 4 | Molecular Pain

Figure 4

From: Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex

Figure 4

Enhancement of synaptic potentiation in GluA2-/- mice. (A) These traces show typical voltage responses to current injections of -100, 0, and 100 pA in ACC neurons from WTCD1 and GluA2-/- mice. Injection of depolarizing currents into neurons induced repetitive action potentials with frequency adaptation that is typical of the firing pattern of pyramidal neurons. (B) LTP was induced in ACC pyramidal neurons in WTCD1 mice (n = 9 slices/5 mice). (C) LTP was enhanced in ACC pyramidal neurons in GluA2-/- mice (n = 8 slices/5 mice) compared with WTCD1 mice. (B-C) The insets show averages of five EPSCs at baseline responses and 30 min after the pairing procedure (arrow). The dashed line indicates the mean basal synaptic responses.

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Molecular Pain

ISSN: 1744-8069

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