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Figure 5 | Molecular Pain

Figure 5

From: Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex

Figure 5

Reduced AMPA receptor-mediated EPSCs in GluA2-/- mice. (A) Input-output relationships for AMPA receptor-mediated EPSCs in WTCD1 (n = 6) and GluA2-/- (n = 6) mice (left). * P < 0.05 compared with WT mice. Traces showing averages of five AMPA receptor-mediated EPSCs with input stimulation at 9 V (right). (B) Paired-pulse facilitaion (PPF) did not differ in WTCD1 (n = 7) and GluA2-/- (n = 13) mice (left). Sample traces of PPF recorded from WTCD1 and GluA2-/- mice at the 50 ms interval (right). (C) Traces of mEPSCs recorded from WTCD1 and GluA2-/- mice (Top). Summary results showing the frequency and the amplitude of mEPSCs in ACC neurons from WT (n = 8) and GluA2-/- (n = 9) mice (Bottom, left). Cumulative probability plot showing the distribution of the inter-event interval and the frequency in WTCD1 (n = 8) and GluA1-/- mice (n = 9) (Bottom, right). (D) Input-output relationships for NMDA receptor-mediated EPSCs in WTCD1 (n = 6) and GluA1-/- mice (n = 6) (left). Traces showing averages of five NMDA receptor-mediated EPSCs with input stimulation at 12 V (right).

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Molecular Pain

ISSN: 1744-8069

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