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Figure 2 | Molecular Pain

Figure 2

From: Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy

Figure 2

Expression of CCR2 mRNA and protein immunoreactivity in rat lumbar DRG ipsilateral to gp120/hCD4 nerve treatment and ddC treatment at post-operative day (POD) 14 and 21. A) Lumbar DRG removed from vehicle-treated animals at POD14 did not exhibit CCR2 mRNA expression (n = 3). B) There was no evidence of CCR2 protein expression in sham animals (n = 3). C) Lumbar DRG neurons from gp120/hCD4 injured rats on POD14 exhibited CCR2 mRNA transcripts in neurons of all sizes (n = 10). D) Lumbar DRG neurons from a rat subjected to gp120/hCD4 treatment only exhibited CCR2 immunopositive small and medium diameter sensory neurons (n = 10). E) In rats treated with a combination of gp120/hCD4 and ddC and sacrificed at POD21, many lumbar DRG neurons exhibited CCR2 mRNA transcripts. F) CCR2 immunoreactivity was also present in numerous neurons at POD21 after combined gp120/hCD4 and ddC treatment. Scale bar: 50 um.

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