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Figure 6 | Molecular Pain

Figure 6

From: Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy

Figure 6

Chemokine expression after gp120/hCD4 alone and following the combination of gp120/hCD4 and ddC treatment. A) MCP1 expression, the ligand for the CCR2 receptor was absent from sham treated animals. B) After gp120/hCD4 treatment, MCP1 expression was upregulated in mostly neurons of the DRG. C) After the combined treatments of gp120/hCD4 and ddC, MCP1 expression was upregulated in a similar manner to that seen in the gp120/hCD4 only treatment. D) SDF1, the ligand for CXCR4, had a basal level of mRNA expression, with the occasional neuron staining positive for the chemokine E) After gp120/hCD4 treatment, the level of SDF1 mRNA expression did not change appreciably, when compared to sham treated animals. F) Following gp120/hCD4 and ddC treatments, SDF1 mRNA expression was upregulated in neurons of all sizes. Arrows: positive cells; arrowheads: negative cells. Scale bar: 100 um.

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