Figure 8

Effect of CCR2 receptor antagonist (RA) and CXCR4 RA on gp120/hCD4 alone and following gp120/hCD4 and ddC-induced decrease in paw withdrawal thresholds (PWT) in the rat. Mechanical hypernociception for the two models was attenuated with antagonists to chemokine receptors. A) CCR2 receptor antagonist administration attenuated existing nociceptive behavior due to gp120/hCD4 administration. In the same animals, intraperitoneal administration of the CXCR4 receptor antagonist, AMD3100, did not affect gp120/hCD4 induced mechanical hypernociception. B) Animals subjected to a combination of gp120/hCD4 and ddC exhibited significant increases in PWT following the administration of AMD3100. Data represent means ± SE; *p < 0.01, n = 10 per treatment condition. POD: post-operative day after gp120/hCD4 treatment; PID: post-injection day after ddC treatment.