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Figure 5 | Molecular Pain

Figure 5

From: Tumor necrosis factor-alpha (TNF-α) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes

Figure 5

Lack of response to 8 hr hypoosmotic challenge by SW982 synoviocytes. Synoviocytes were poorly responsive to hypoosmotic challenge after 2, 4, or 8 hr TNF-α pre-treatment A and B: Representative calcium traces show responses to 50% hypoosmolar saline (150 mOsm/l) (A) in the absence or (B) presence of TRPV4 channel blocker ruthenium red (10 μM, 5 min pretreatment). (C) Peak and average calcium response to 50% hypoosmotic stimulation in control (n = 11 cells) or TNF-α (1 ng/ml, 8 hr) treated (n = 6 cells) synoviocytes.

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Molecular Pain

ISSN: 1744-8069

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