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Figure 8 | Molecular Pain

Figure 8

From: Tumor necrosis factor-alpha (TNF-α) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes

Figure 8

TNF-α increases of TRPV1 protein expression in SW982 synoviocytes. (A) Western Blot analysis was done on whole cell and subcellular protein fractions extracted from synoviocytes. The TNF-α stimulated increase in expression of TRPV1 protein was significant at 8 hr in the membrane fraction (n = 3 trials), implying a functional role for TRPV1 in the inflamed joint. (B) While TRPV4 mRNA was elevated in the RT-PCR analysis at 8 hr (Fig. 7), a significant increase in TRPV4 protein was not yet evident at the 8 hr time point tested. * indicates a statistically significant difference from control synoviocyte cultures (p < 0.05) tested with unpaired Student's t-test.

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Molecular Pain

ISSN: 1744-8069

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