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Figure 6 | Molecular Pain

Figure 6

From: Modulation of transient receptor potential vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C

Figure 6

Potentiation of 4α-PDD-induced changes in synaptic transmission by PDBu in DRG-DH co-cultures. A. Application of 4α-PDD (40 μM) increases the frequency of mEPSCs and this action is enhanced by incubation with PDBu (1 μM). Synaptic currents are shown at a higher time resolution below. B. Cumulative probability plot indicates an increase in the frequency of synaptic events with 4α-PDD, which is further significantly enhanced following by PDBu incubation. C. The increase in frequency of events is not accompanied by a change in the amplitude. D. Summary graphs showing 4α-PDD-induced an increase in mEPSC frequency (n = 5) and potentiation by PDBu (n = 3). The asterisk (*) represents P < 0.05 as compared to control; (**) represents P < 0.05 as compared to 4α-PDD group.

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Molecular Pain

ISSN: 1744-8069

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