Skip to main content
Figure 2 | Molecular Pain

Figure 2

From: Signal Transduction Mechanisms Underlying Group I mGluR-mediated Increase in Frequency and Amplitude of Spontaneous EPSCs in the Spinal Trigeminal Subnucleus Oralis of the Rat

Figure 2

Pharmacological characterization of the DHPG-induced increase of sEPSC frequency and amplitude. Representative sEPSC traces, recorded from Vo neurons, before and during bath application of 10 μM DHPG (5 min) in the presence of the selective mGluR1 antagonist LY367385 (100 μM; Aa), the selective mGluR5 antagonist MPEP (10 μM; Ba), and LY367385+MPEP (Ca). Time-course graphs demonstrate the DHPG-induced changes of mean frequency (Ab, Bb and Cb) and amplitude (Ac, Bc and Cb) in LY367385 (n = 5), MPEP (n = 4) and LY367385+MPEP (n = 5). Numbers on the graphs indicate the corresponding time of the traces sampled. Histograms compare the magnitudes of DHPG-induced increases in sEPSC frequency (D) and amplitude (E) during the application (filled) or the washout (open) of DHPG in the presence of different antagonists including TTX (1 μM; n = 4), a Na+ channel blocker. Asterisks indicate significant differences of DHPG effects, compared to the effect in the Krebs condition (**P < 0.01; *P < 0.05).

Back to article page