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Figure 4 | Molecular Pain

Figure 4

From: Signal Transduction Mechanisms Underlying Group I mGluR-mediated Increase in Frequency and Amplitude of Spontaneous EPSCs in the Spinal Trigeminal Subnucleus Oralis of the Rat

Figure 4

Effects of GF109203X alone and with LY367385 or MPEP on the DHPG-induced increases of sEPSC frequency and amplitude. Representative sEPSC traces before and during bath application of 10 μM DHPG (5 min) in the presence of the PKC inhibitor GF109203X (1 μM) alone (Aa) and with LY367385 (50 μM; Ba) or MPEP (10 μM; Ca). Time-course graphs demonstrate the DHPG-induced changes of mean frequency (Ab, Bb and Cb) and amplitude (Ac, Bc and Cb) in GF109203X (n = 7), GF109203X + LY367385 (n = 6) and GF109203X + MPEP (n = 5). Numbers on the graphs indicate the corresponding time of the traces sampled. Histograms compare magnitudes of DHPG-induced increases in sEPSC frequency (D) and amplitude (E) during the application (filled) or the washout (open) of DHPG in the presence of GF109203X (n = 7), GF109203X + LY367385 (n = 6) and GF109203X + MPEP (n = 5). Asterisks indicate significant differences of DHPG effects between two conditions indicated by lines (**P < 0.01; *P < 0.05).

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Molecular Pain

ISSN: 1744-8069

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