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Figure 5 | Molecular Pain

Figure 5

From: Signal Transduction Mechanisms Underlying Group I mGluR-mediated Increase in Frequency and Amplitude of Spontaneous EPSCs in the Spinal Trigeminal Subnucleus Oralis of the Rat

Figure 5

Effects of L-NAME, PTIO and ODQ on the DHPG-induced increases of sEPSC frequency and amplitude. Representative sEPSC traces before and during bath application of 10 μM DHPG (5 min) in the presence of the NOS inhibitor L-NAME (100 μM; Aa), the NO scavenger PTIO (10 μM; Ba) and the NO-sensitive guanylate cyclase inhibitor ODQ (10 μM; Ca). Time-course graphs demonstrate the DHPG-induced changes of mean frequency (Ab, Bb and Cb) and amplitude (Ac, Bc and Cb) in L-NAME (n = 5), PTIO (n = 6) and ODQ (n = 6). Numbers on the graphs indicate the corresponding time of the traces sampled. Histograms compare magnitudes of DHPG-induced increases in sEPSC frequency (D) and amplitude (E) during the application (filled) or the washout (open) of DHPG in the presence of L-NAME (n = 5), PTIO (n = 6) or ODQ (n = 6). Asterisks indicate significant differences of DHPG effects, compared to the effect in the Krebs condition (**P < 0.01; *P < 0.05).

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