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Figure 6 | Molecular Pain

Figure 6

From: Signal Transduction Mechanisms Underlying Group I mGluR-mediated Increase in Frequency and Amplitude of Spontaneous EPSCs in the Spinal Trigeminal Subnucleus Oralis of the Rat

Figure 6

Effects of KN-62 and PD98059 on the DHPG-induced increases of sEPSC frequency and amplitude. Representative sEPSC traces before and during bath application of 10 μM DHPG (5 min) in the presence of the CaMKII inhibitor KN-62 (3.5 μM; Aa) and the MEK inhibitor PD98059 (50 μM; Ba). Time-course graphs demonstrate the DHPG-induced changes of mean frequency (Ab, Bb and Cb) and amplitude (Ac, Bc and Cb) in KN-62 (n = 5) and PD98059 (n = 6). Numbers on the graphs indicate the corresponding time of the traces sampled. Histograms compare magnitudes of DHPG-induced increases in sEPSC frequency (D) and amplitude (E) during the application (filled) or the washout (open) of DHPG in the presence of KN-62 (n = 5) or PD98059 (n = 6). Asterisks indicate significant differences of DHPG effects, compared to the effect in the Krebs condition (**P < 0.01; *P < 0.05).

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Molecular Pain

ISSN: 1744-8069

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