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Figure 3 | Molecular Pain

Figure 3

From: Short-term synaptic plasticity in the nociceptive thalamic-anterior cingulate pathway

Figure 3

Effects of high-frequency, paired-pulse stimulation on ACC responses in vivio. A. Diagram depicting the locations of the 2 multichannel probes used to simultaneously record activities from the MD thalamic nucleus and ACC. B. Example of enhanced ACC responses and MITN unit activities after high-frequency sciatic nerve stimulation (100 Hz, 11 pulses). C. Diagram of a multichannel probe used to record activities from the ACC and a tungsten electrode used to stimulate the MD nucleus. Black dots represent the stimulating sites. D. evoked CSD profile after direct stimulation of the MD nucleus. Paired-pulse facilitation was observed in ACC layer II/III CSD responses evoked by direct electrical stimulation of the MD nucleus when pulses were delayed 50 to 100 ms (n = 5; **P < 0.01). Abbreviations: CL, centrolateral thalamic nucleus; MD, mediodorsal thalamic nucleus; PC, paracentral thalamic nucleus; VL, ventrolateral thalamic nucleus; VPL, ventral posterolateral thalamic nucleus; VPM, ventral posteromedial thalamic nucleus (Modified from 45)

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