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Figure 12 | Molecular Pain

Figure 12

From: Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording

Figure 12

Effects of bath application of AP5 (100 μM) or CNQX (10 μM), at 120 min after long-term potentiation induction, on the mean averaged number of field excitatory postsynaptic potential (fEPSP) that could be reliably recorded over the whole screen in naïve, saline (Sal-control), and bee venom (BV)-inflamed group of slices. A, two-dimensional current source density imaging of changes in spatial distribution of current sources and sinks across the dentate gyrus and CA1 area before (Pre-drug) and after (Post-drug) AP5 (upper) or CNQX (lower) infusion in saline control (left) and BV-inflamed (right) groups. For other legends, see Fig. 3. B, bar histogram showing the quantification data. Note the significant increase in the number of fEPSP following BV-induced persistent pain. Application of CNQX (right) but not AP5 (left), resulted in a marked reduction of the number in each group. In the left panel, n = 12, 15 and 14 for naïve, saline and BV-inflamed group, respectively; in the right panel, n = 13, 15 and 13 for naïve, saline and BV-inflamed group, respectively. *P < 0.05 vs. Sal-control or naïve; ##P < 0.01, vs. Pre-drug. Error bars: ± S.E.M.

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