Figure 3

Showing two-dimensional current source density (2D-CSD) imaging of 8 × 8 array (inset, interelectrode spacing: 300 μm, scale bar: 600 μm) recordings in the hippocampal formation. A, an example of 2D-CSD imaging of network response across the dentate gyrus (DG) and CA1 area to theta burst stimulation (TBS) of the perforant path (PP) on the hippocampal slice of a rat receiving saline injection (Sal-control). B, an example of 2D-CSD imaging of network responses across the DG and CA1 area to the PP TBS conditioning on the hippocampal slice of a rat receiving bee venom injection (BV-inflamed). Recordings were taken from 63 sites in the hippocampal slice in response to PP electrical stimulation (red dots). Each imaging represents the instantaneous 2D-CSD plots computed at selected time points, indicated at the bottom of each column. Current sinks are depicted in blue and current sources are shown in yellow. The positions of the pyramidal and granule cell bodies are marked by red, dashed lines. Pre-TBS, baseline; Post-TBS, 120 min after TBS conditioning. Note the conversion from single current source-sink dipole to binomial events after TBS in the BV-inflamed group.