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Figure 7 | Molecular Pain

Figure 7

From: Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording

Figure 7

Showing two-dimensional current source density (2D-CSD) imaging and quantitative analysis of spatial plasticity of synaptic connection in the hippocampal formation (HF) following formalin (F)-induced persistent pain. A, the 2D-CSD images of current sources and sinks around the HF in response to electrical stimulation of the perforant pathway at an intensity of 60 μA (about half of the maximum amplitude). The lower two pictures are the original hippocampal slices from which the CSD plots were derived. For other legends, see Fig. 3. B, stimulus intensity-network response functional curves showing the mean averaged number of field excitatory postsynaptic potential (fEPSP) that was reliably evoked (>20% baseline) across the 8 × 8 arrays with the increasing stimulus intensity in saline (Sal-control), and F-inflamed group of slices. Note the significant increase in the number of fEPSP following F-induced persistent pain at the stimulation intensity of 120 μA, 180 μA and 199 μA. The number of slices for each group is shown in parentheses. *P < 0.05 vs. saline control. Error bars: ± S.E.M.

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