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Figure 1 | Molecular Pain

Figure 1

From: Delayed onset of changes in soma action potential genesis in nociceptive A-beta DRG neurons in vivo in a rat model of osteoarthritis

Figure 1

Representative APs evoked in Aβ nociceptive neurons by dorsal root stimulation. A-C, evoked APs; D-F, differentiated derivatives of these APs to determine rate of change. A and D are from a nociceptive neuron that could be activated only by high intensity stimuli, including firm pinch applied to the ankle joint; conduction velocity was 12.4 m/s. B and E are from an unresponsive neuron classified as an Aβ fiber on the basis of conduction velocity, which was 8 m/s, and a plateau was identified on the repolarisation branch of the AP in the differentiated recording, which is indicative of a nociceptive neuron. C and F are from another unresponsive neuron, with a conduction velocity of 18.8 m/s, but with no inflection on the falling phase in the differentiated recording, which is considered a non-nociceptive neuron.

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