Figure 2

Resting membrane potential (Vm) and action potential (AP) amplitude in Aβ nociceptive DRG neurons in osteoarthritis (OA) animals at one month and at two months, and in naïve control animals. "Naive" represents Aβ-fiber HTMs in control animals. "Unrespon" represents nociceptor-like Aβ-fiber unresponsive neurons in one month OA animals; an inflection on the falling phase of the differentiated recording was used to classify these neurons [22, 34]. "HTM-1m" and "HTM-2m" represent Aβ-fiber HTMs from the OA group tested one month or two months after model induction, respectively. One way ANOVA with Newman-Keuls post test was used for multiple comparisons among "Naive" (N = 23), "Unrespon" (N = 13 for Vm and N = 14 for AP amplitude), "HTM-1m" (N = 17 for Vm and N = 18 for AP amplitude), "HTM-2m" (N = 13 for Vm and N = 15 for AP amplitude). In each case the mean (horizontal line) is presented.