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Table 1 Properties of all the nociceptive DRG neurons recorded in control and osteoarthritis animals

From: Delayed onset of changes in soma action potential genesis in nociceptive A-beta DRG neurons in vivo in a rat model of osteoarthritis

Parameter

Naïve

Unrespon-1m

HTM-1m

HTM-2m

Vm (mV)

-64.66 ± 1.71,

N = 23

-56.25 ± 1.23,

N = 13

-63.65 ± 1.85,

N = 17

-61.72 ± 1.62,

N = 13

Amplitude (mV)

72.47 ± 2.04,

N = 23

84.01 ± 2.33,

N = 14

77.52 ± 2.35,

N = 18

83.19 ± 2.4,

N = 15

APD (ms)

1.56 ± 0.11,

N = 23

1.79 ± 0.16,

N = 14

1.68 ± 0.1,

N = 18

1.13 ± 0.09,

N = 15

Half width (ms)

0.78 ± 0.05,

N = 23

1 ± 0.09,

N = 14

0.86 ± 0.06,

N = 18

0.56 ± 0.05,

N = 15

Rise time (ms)

0.66 ± 0.06,

N = 23

0.71 ± 0.06,

N = 14

0.64 ± 0.04,

N = 18

0.47 ± 0.04,

N = 15

MRR (mV/ms)

239.1 ± 19.23,

N = 23

228.8 ± 18.52,

N = 14

239.1 ± 12.49,

N = 18

350.4 ± 28.09,

N = 15

Fall time (ms)

0.9 ± 0.05,

N = 23

1.09 ± 0.1,

N = 14

1.04 ± 0.06,

N = 18

0.66 ± 0.05,

N = 15

MFR (mV/ms)

135.7 ± 10.23,

N = 23

121.1 ± 11.29,

N = 14

124.3 ± 7.33,

N = 18

197.5 ± 14.66,

N = 15

AHP (mV)

10.7 ± 0.68,

N = 23

11.78 ± 1.05,

N = 13

12.19 ± 0.69,

N = 15

10.11 ± 0.71,

N = 14

AHP80 (ms)

30.95 ± 5,

N = 22

35.9 ± 7.46,

N = 13

34.71 ± 4.82,

N = 15

21.01 ± 4.92,

N = 14

AHP50 (ms)

8.99 ± 1.29,

N = 22

9.6 ± 1.73,

N = 13

8.67 ± 1.48,

N = 15

5.71 ± 1.62,

N = 14

CV (mm/ms)

14.1 ± 1,

N = 23

11.69 ± 0.8,

N = 14

13.24 ± 0.66,

N = 18

16.38 ± 1.42,

N = 15

  1. "Naive" represents Aβ-fiber HTMs in control animals. "Unrespon-1m" represents nociceptor-like Aβ-fiber unresponsive neurons in one month OA animals. "HTM-1m" and "HTM-2m" represent Aβ-fiber HTMs from the OA group tested one month or two months after model induction, respectively. Values are presented as mean ± S.E.M. "N" represents the number of neurons.