Table 1 A summary of the changes in levels of endocannabinoid and related compounds in models of inflammatory and neuropathic pain.
From: Dynamic regulation of the endocannabinoid system: implications for analgesia
Model | Tissue | AEA | 2-AG | PEA | OEA | Reference | |
|---|---|---|---|---|---|---|---|
Inflammatory Pain | |||||||
Formalin | Rat | Hindpaw skin | ⇔ | ⇔ | - | - | [92] |
Rat | Hindpaw skin | ⇔ | ⇓ | ⇔ | - | [91] | |
Mouse | Hindpaw Skin | ⇓ | ⇓ | ⇓ | - | [91] | |
Carrageenan | Rat | Hindpaw skin | ⇓ | ⇓ | ⇓ | ⇔ | [26] |
Neuropathic Pain | |||||||
Spinal Nerve Ligation | Rat | L5 DRG | ⇑ (day14) | ⇑ (day 14) | - | - | [95] |
Rat | L4 DRG | ⇔ (day 14) | ⇔ (day 14) | - | - | [95] | |
Rat | Lumbar Spinal Cord | ⇑ (day 14) | ⇑ (day 14) | ⇓ (day 14) | ⇔ (day 14) | [96] | |
Rat | Brain (Thalamus) | ⇔ (day 14) | ⇔ (day 14) | ⇔ (day 14) | ⇔ (day 14) | [65] | |
Chronic Constriction Injury | Rat | Lumbar Spinal Cord | ⇑ (days 3 & 7) | ⇑ (days 3 & 7) | ⇑ (day 3) ⇔ (day 7) | - | [139] |
Rat | Brain (PAG) | ⇑ (days 3 & 7) | ⇑ (days 3 & 7) | ⇔ (days 3 & 7) | - | [139] | |
Rat | Brain (RVM) | ⇔ (day 3) ⇑ (day 7) | ⇔ (day 3) ⇑ (day 7) | ⇔ (days 3 & 7) | - | [139] | |
Rat | Brain (DR) | ⇔ (day 3) ⇑ (day 7) | ⇔ (days 3 & 7) | ⇔ (days 3 & 7) | - | [139] | |
Rat | Brain | ⇔ (day 14) | ⇔ (day 14) | - | - | [133] | |
Rat | Spinal cord | ⇔ (day 14) | ⇔ (day 14) | - | - | [133] | |