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Figure 3 | Molecular Pain

Figure 3

From: Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Figure 3

Intrathecal AMPA/kainate receptor antagonists reverse tactile allodynia in the TG mice. Different doses of DNQX, an antagonist of AMPA/kainate receptors, were injected intrathecally between L5/6 lumbar regions into adult TG and WT mice, and behavioral sensitivities to mechanical stimulation before or after drug treatments were assessed blindly as paw withdrawal thresholds (PWT) to von Frey filament stimulation in the hindpaw. Data shown are the dose- and time-dependent effects of intrathecal DNQX on allodynia reversal in TG mice compared with saline treatment or similar treatment in the WT mice. For the purpose of clarity, effects of the lower dose of DNQX (50 μg/kg) on PWT of WT mice, which were similar to that in saline treated WT mice, were not shown. Means ± SEM from n = 7 for each group. ** p < 0.01, *** p < 0.001 compared with the pretreatment level, $ p < 0.05, $$$ p < 0.001 compared with saline treatment in TG mice using two-way ANOVA followed by Bonferroni post-tests.

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