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Figure 4 | Molecular Pain

Figure 4

From: Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Figure 4

Intrathecal antagonism of metabotropic glutamate receptors does not cause allodynia reversal in the TG mice. AP3, a mGluR antagonist, was injected intrathecally between L5/6 lumbar regions into adult TG and WT mice, and behavioral sensitivities to mechanical stimulation before or after drug treatments were assessed blindly as paw withdrawal thresholds (PWT) to von Frey filament stimulation in the hindpaw. Data shown are time-dependent effects of intrathecal AP3, at the maximum tolerable dose (50 μg/kg), on PWT of TG and WT mice. Means ± SEM from n = 7 for each group.

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Molecular Pain

ISSN: 1744-8069

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