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Figure 6 | Molecular Pain

Figure 6

From: Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Figure 6

Increased frequency, but not amplitude, of AMPA/kainate- and NMDA-receptor mediated mEPSCs in deep-dorsal horn neurons of the TG mice. Spinal cord slices were prepared from the WT and TG mice, and spontaneous mEPSCs were recorded blindly from deep-dorsal horn neurons. A. Representative traces mediated by AMPA/kainate and NMDA receptors, respectively. B. Summarized mEPSC frequency (left) and amplitude (right) from WT and TG neurons mediated by AMPA/kainate and NMDA receptors, respectively. C. Representative traces of AMPA/kainite receptor mediated mEPSCs recorded from WT and TG neurons. D. Summarized mEPSC rising time (left) and decay time constant (right) from WT and TG neurons mediated by AMPA/kainate and NMDA receptors, respectively. Data presented are the means ± SEM from the number of independent neurons indicated in the text. Statistic significance is indicated by p < 0.01 using unpaired Students' t test. n.s. – not significant

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Molecular Pain

ISSN: 1744-8069

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