Figure 1

TrkB.T1 expression in the spinal dorsal horn of d4T and CFA-treated mice A. Quantification of trkB.T1 mRNA expression in the dorsal horn of wildtype mice 3 hours after receiving a saline tail injection (black bar; n = 6) or an injection of d4T [50 mg/kg] (blue bar; n = 6). B. TrkB.T1 protein expression in the dorsal horn in the antiretroviral model was assayed via western blot. The top panel shows a representative western blot of trkB.T1 following saline or d4T injection at 1d and 3d. Below the panel the results from saline treated (black bar; n = 6) and 1d (blue bar; n = 6) or 3d (red bar; n = 6) after d4T treatment are quantified. *indicates p < 0.05 by ANOVA with Tukey post-hoc testing. C. Quantification of trkB.T1 mRNA expression in the dorsal horn of wildtype mice 3 days after receiving a saline hind paw injection (black bar; n = 6) or an injection of CFA (blue bar; n = 6). D. TrkB.T1 protein expression in the dorsal horn in the CFA model was assayed via western blot. The top panel shows a representative western blot of trkB.T1 following a saline or CFA hind paw injection at 3d. Below the panel the results from saline treated (black bar; n = 6) and 3d CFA (blue bar; n = 6) are quantified. *indicates p < 0.05 by t-test.