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Figure 7 | Molecular Pain

Figure 7

From: Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels

Figure 7

Differential block of voltage-activated TRPM8-Y745H by BCTC and SKF96365. Whole-cell I-V curves from voltage ramps (-100/+150 mV) of TRPM8-wt and TRPM8-Y745H expressing HEK293 cells at 33°C in the presence and absence of A, 3 μM BCTC; and B, 3 μM SKF96365. C, Summary histogram of experiments seen in A and B, showing the block of voltage-evoked currents by BCTC and SKF96365 at a membrane potential of +120 mV. Statistical significance was assessed with the unpaired t-test: ** p < 0.01, n = 2-5.

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