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Figure 4 | Molecular Pain

Figure 4

From: Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord

Figure 4

Modulation induced by TGOT on properties of sustained (IKDR) and transient (I A ) potassium currents. A: Voltage/current relationship of the sustained (left graph) and transient K+ currents (right graph) observed in a lamina II neuron in control (black circles) and after bath application of TGOT (1 μM, white circles). A typical current, obtained at a membrane potential of +50 mV, is shown in inset for both current components in control condition (black line) and after TGOT (dotted line). B, C: Activation (B) and inactivation curves (C) of sustained (left graphs) and transient components of K+ currents (right graphs), respectively. Mean data are shown for 11 neurons, each recorded in the control situation (black circles and lines) and after application of 1 μM TGOT (white circles and dotted lines). All experiments were conducted in the presence of a steady-state concentration of TTX (0.5 μM). Values are expressed as means ± S.E.M.

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Molecular Pain

ISSN: 1744-8069

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