Modulation induced by TGOT on properties of sustained (IKDR) and transient (I
) potassium currents. A: Voltage/current relationship of the sustained (left graph) and transient K+ currents (right graph) observed in a lamina II neuron in control (black circles) and after bath application of TGOT (1 μM, white circles). A typical current, obtained at a membrane potential of +50 mV, is shown in inset for both current components in control condition (black line) and after TGOT (dotted line). B, C: Activation (B) and inactivation curves (C) of sustained (left graphs) and transient components of K+ currents (right graphs), respectively. Mean data are shown for 11 neurons, each recorded in the control situation (black circles and lines) and after application of 1 μM TGOT (white circles and dotted lines). All experiments were conducted in the presence of a steady-state concentration of TTX (0.5 μM). Values are expressed as means ± S.E.M.