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Figure 1 | Molecular Pain

Figure 1

From: Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain

Figure 1

Lysophosphatidylcholine (LPC) induces lysophosphatidic acid (LPA) production in the spinal dorsal horn and dorsal roots. (a) The exact regions of removed samples, including dorsal horn of lumbar spinal cord (SC), dorsal roots (DR), dorsal root ganglions (DRG), spinal nerves (SPN) and sciatic nerves (SCN). (b and c) Quantification of LPA production at different time points after the LPC treatment. The capital letter "C" showed on the time course axis represents the vehicle group. (d) LPC-induced LPA production in different preparations from SC, DR, DRG, SPN and SCN at 1 and 3 h post-treatment. The measurement of LPA was carried out in triplicate of each sample. All data represent the mean ± SEM from three separate experiments. Rounding morphology was evaluated in at least 500 enhanced green fluorescence-positive cells. *p < 0.05 compared with the vehicle group.

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