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Figure 2 | Molecular Pain

Figure 2

From: Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain

Figure 2

ATX and LPA 3 receptors are required for LPC-induced LPA production. (a and b) Quantification of LPA production by LPC-treated tissue extraction from the SC and DR of wild-type (WT) mice and ATXgene heterozygous mutant (atx+/-) mice at 1 (panel a) and 3 h (panel b) post-treatment. (c and d) LPC-induced LPA production in the SC (panel c) and DR (panel d) from WT, Lpar1-/-, Lpar2-/- and Lpar3-/- mice at 3 h post-treatment. Three female atx+/- mice were used in this experiment, but no significant difference was observed compared with other male mice. *p < 0.05 compared with the WT group. Other details are shown in the legend of Figure 1.

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Molecular Pain

ISSN: 1744-8069

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